Convergent mechanisms of longevity – supported by LIMNA

Abstract

Research in model organisms over the last several decades has revealed that animal lifespan is plastic and regulated by conserved metabolic signaling pathways, which work through specific transcription factors to extend life. Whether these pathways affect common downstream mechanisms remains largely elusive. Our studies in C. elegans reveal that the helix-loop-helix transcription factors, MML-1/Mondo, MXL-2/Max-like and HLH-30/TFEB work in an integrated network to regulate life span across the major longevity pathways, and are interlinked via mTOR signaling. More recently, we have discovered that a major focal point of convergent regulation is the nucleolus. In my talk, I will discuss how major longevity pathways impinge upon these processes.